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2004/12/21, 02:54 AM
Based on claims that DMG is a highly potent "oxygenator" of body/brain tissues, this supplement has been touted as a panacea for years.
Several studies show that DMG has no anticonvulsant value and is thus of no help in epilepsy or other conditions characterized by seizures. Persistent claims that DMG is useful in autism are thus far anecdotal.
Claims that DMG can boost energy and athletic performance have been refuted by human and animal studies. Tests on exercising thoroughbred horses found "no beneficial effects on cardiorespiratory function or lactate production." And male track athletes supplemented with DMG exhibited no significant changes in short-term maximal treadmill performance.
On the other hand, an early finding that DMG can enhance both humoral and cell-mediated immune responses has been fortified by some subsequent research. This animal research needs to be extended to humans.
Early fears that DMG might be mutagenic now appear to be unfounded.
LITERATURE
Bolman WM, Richmond JA. A double-blind, placebo-controlled crossover pilot trial of low dose dimethylglycine in patients with autistic disorder. J Autism Dev Disord. 1999; 29:191-194.
Gascon G, Patterson B, Yearwood K, Slotnick H. N, N-dimethylglycine and epilepsy. Epilepsia. 1989; 30:90-93.
Graber CD, Goust JM, Glassman AD, et al. Immunomodulating properties of dimethylglycine in humans. J Infect Dis. 1981; 143:101-105.
Gray ME, Titlow LW. The effect of pangamic acid on maximal treadmill performance. Med Sci Sports Exerc. 1982; 14:424-427.
Hoorn AJ. Dimethylglycine and chemically related amines tested for mutagenicity under potential nitrosation conditions. Mutat Res. 1989; 222:343-350.
Moolenaar SH, Paggi-Bach J, Engelke UF, et al. Defect in dimethylglycine dehydrogenase, a new inborn error of metabolism: NMR spectroscopy study. Clin Chem. 1999; 45:459-464.
Reap EA, Lawson JW. Stimulation of the immune response by dimethylglycine, a nontoxic metabolite. J Lab Clin Med. 1990; 115:481-486.
Rose RJ, Schlierf HA. Knight PK, et al. Effects of N, N-dimethylglycine on cardiorespiratory function and lactate performance in thoroughbred horses performing incremental treadmill exercise. Vet Rec. 1989; 125; 268-271.
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Michael
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