Hi there, I'm curious to know, I used creatine for about 6 days before I started to suffer terrible pains in my ankles. Now I put this down to creatine causing increased blood pressure and water retention (diabetics have to take care of their feet and watch our circulation). I have been doing research into creatine serum. As the serum is 100% soluble I know it removes the prior risks I have mentioned. However I wish to know if any one knows what effects glucosamine may have on my insulin sensitivity as it is common in creatine serum.