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2005/06/23, 08:57 PM
So I ordered 7-Keto from www.vitamins.com to take the recommended dosage of 200mg a day(divided in 2).....so I got 1 bottle from DPS as bb1 suggested, however that would only last 15 days....so i got generic for another 60 days....so I could do it for 6 weeks....
however what got me was that at only 25mg suggested dosage...it listed a myriad of warnings...and warned against going beyond this 'recommended' 25 mg a day dosage....so now I am wondering if the 200mg dosage is safe? I thought i read it doesn't increase testosterone or convert into estrogen?
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7-keto is a highly active derivative of DHEA and is one supplement of which its pharmacokinetic (dictionary) profile is needed if we want to ascertain when peak levels occur in plasma. This information will help prescribe the best possible rational for its time of use, dosage, and safety to optimise body compositional changes.
A series of trials have looked at both the safety and pharmacokinetics of 7-keto (see Fig. 2 below.). In animal studies, 7-Keto was shown to be safe and in effect non-toxic to levels of 2000mg/kg in rats9 and 1000mg/kg in monkeys10. Toxicity was assessed by full-blood chemistry, blood cell counts and histological examination in 42 different tissues. Again caution must be taken until we see the human data; so what human data does exist? Davidson et al11 studied a series of doses ranging from 50mg/d (25mg twice daily) for 7 days; 100mg/d (50mg twice daily) for 7 days; and finally 200mg/d (100mg twice for 28 days). Results demonstrated that at all doses, 7-keto in comparison to a placebo presented no substantial impact on clinical blood markers of toxicity and health. This data was supported in further human trials12-13.
One other important point that really separates the function of 7-keto from DHEA, is the effects it has on androgenic and estrogenic compounds. In a landmark study14 investigating the androgenic activity of 7-keto, researchers unequivocally demonstrated that in human prostate cells 7-keto had no effect on androgen receptor (AR) activity. There are two problems in using this study to conclusively prove that 7-keto has no effect on AR activity.
1. This study is the primary study referenced to convince us that 7-keto has no androgenic effects, however the study uses cell lines (cells grown in a dish not in the body) to demonstrate this point.
2. Cell lines have a series of methodological problems in proving the data to be clinically relevant15.
The study / model uses abnormal cells (cancer cells) to prove there is no androgenic activity which makes it even more difficult to prove that similar non androgenic effects would be found in healthy human cells. Use of a model that relies on animal or human grafts using healthy tissues would have provided a more realistic view and an insight into the application of this therapeutic agent in a real world setting. Adding to this supposition recent data11 has shown free testosterone is significantly elevated (14.4% above baseline) following 7-keto administration. These values are a magnitude less than those associated with the direct use of DHEA and although significant constitute little clinical relevance. For these reasons an androgenic influence of 7-keto DHEA cannot be ruled out with 100% conviction therefore more research is needed in this area.
Pharmacokinetic data has revealed that based on a 100mg (200mg/d) dose, the highest tested to-date, is safe and peaks in concentration in plasma after around 2 hours and returns back to baseline after around 5-6 hours (see Fig.2 below). We will come back to this later and link it in with some practical applications.
are makers of 7-Keto covering the butts in case of a lawsuit or is it truly this dangerous?
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2005/06/24, 12:19 PM
thanks bb1, I think they are trying to cover their butts....just in case...
because they were listing all sorts of things
I found the labbel:
Prod. No. 60369
Shop Online www.puritan.com
7-KETO
DHEA
25mg
7-Keto™ DHEA
Patented Formula
Backed by
Laboratory Studies
60
Softgels B60369 03C
Supplement Facts
Serving Size 1 softgel
Amount Per Serving %Daily Value
7-Keto™-Dehydroepiandrosterone
Acetate 25 mg *
*Daily Value not established.
Carefully Manufactured for
PURITAN’S PRIDE, INC.
Oakdale, NY 11769 U.S.A.
©Puritan’s Pride, Inc., 2005
Good
Manufacturing
Practices
Other Ingredients: Soybean Oil, Gelatin,
Lecithin, Beeswax/Soybean Oil Mixture,
Glycerin, Titanium Dioxide Color.
DIRECTIONS: For adults, take one
(1) softgel daily, preferably with a
meal.
7-Keto™ is a registered trademark of
Humanetics Corporation.
KEEP OUT OF REACH OF CHILDREN. STORE IN A
COOL, DRY PLACE. TAMPER RESISTANT: DO NOT
USE IF IMPRINTED SEAL UNDER CAP IS BROKEN.
To report any adverse events call
1-800-332-1088.
WE HAVE ASSAYED & FULLY
GUARANTEE THE QUALITY &
POTENCY OF THIS PRODUCT
WARNING: NOT FOR USE BY INDIVIDUALS UNDER THE
AGE OF 18 YEARS. DO NOT USE IF PREGNANT OR
NURSING. Consult a physician or licensed qualified health
care professional before using this product if you have, or
have a family history of, prostate cancer, prostate enlargement,
breast cancer, hormone-sensitive disorder, heart
disease, low "good" cholesterol (HDL), high blood pressure,
heart disease, diabetes, an autoimmune disorder,
liver disease, kidney disease, thyroid disorder, psychiatric
problem, pernicious anemia, nervousness, anxiety, seizure
disorder, stroke, are under age 40 or if you are using any
other dietary supplement, prescription drug, including
MAO inhibitors, or over-the-counter drug. Do not exceed
recommended serving. Exceeding recommended serving
may cause serious adverse health effects. Possible side
effects include acne, oily skin, hair loss, hair growth on the
face (in women), increased perspiration, aggressiveness,
irritability and increased levels of estrogen. Discontinue
use and call a physician or licensed qualified health care
professional immediately if you experience rapid heartbeat,
dizziness, blurred vision, insomnia, tremors, nervousness,
unwanted hair growth, deepening of voice,
headache, weight gain, mood changes, high blood pressure,
changes in blood lipid levels, breast tenderness,
menstrual irregularities or other similar symptoms.
0
5 25077 60369 Dietary Supplement
™
Prod. No. 60369
TO REORDER
CALL
1-800-645-1030
Prod. No. 60369
TO REORDER CALL
1-800-645-1030
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