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2006/02/02, 01:44 PM
This is in response to a PM, but I figured other people might be interested.
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Multiple effects of caffeine on simulated high-intensity team-sport performance.
Stuart GR, Hopkins WG, Cook C, Cairns SP.
Division of Sport and Recreation, Auckland University of Technology, New Zealand.
INTRODUCTION: Caffeine enhances performance of single bouts of endurance exercise, but its effects on repeated bouts typical of those in high-intensity team sports are unclear. PURPOSE: To investigate effects of caffeine in a performance test simulating physical and skill demands of a rugby union game. METHODS: The study was a double-blind, randomized, crossover design in which nine competitive male rugby players ingested either caffeine (6 mg.kg(-1) body mass) or placebo (dextrose) 70 min before performing a rugby test. Each test consisted of seven circuits in each of two 40-min halves with a 10-min half-time rest. Each circuit included stations for measurement of sprint time (two straight-line and three agility sprints), power generation in two consecutive drives, and accuracy for passing balls rapidly. Interstitial fluid was sampled transdermally by electrosonophoresis before ingestion of caffeine or placebo and then before testing, at half-time, and immediately after testing; samples were assayed chromatographically for caffeine and epinephrine concentrations. RESULTS: The effects of caffeine on mean performance (+/-90% confidence limits) over all 14 circuits were: sprint speeds, 0.5% (+/-1.7%) through 2.9% (+/-1.3%); first-drive power, 5.0% (+/-2.5%); second-drive power, -1.2% (+/-6.8%); and passing accuracy, 9.6% (+/-6.1%). The enhancements were mediated partly through a reduction of fatigue that developed throughout the test and partly by enhanced performance for some measures from the first circuit. Caffeine produced a 51% (+/-11%) increase in mean epinephrine concentration; correlations between individual changes in epinephrine concentration and changes in performance were mostly unclear, but there were some strong positive correlations with sprint speeds and a strong negative correlation with passing accuracy. CONCLUSION: Caffeine is likely to produce substantial enhancement of several aspects of high-intensity team-sport performance.
Effects of caffeine, ephedrine and their combination on time to exhaustion during high-intensity exercise.
Bell DG, Jacobs I, Zamecnik J.
Defence and Civil Institute of Environmental Medicine, North York, Ontario, Canada.
This study investigated the effects of acute ingestion of caffeine (C), ephedrine (E) and their combination (C+E) on time to exhaustion during high-intensity exercise. Using a repeated-measures, double-blind design, eight male subjects exercised on a cycle ergometer at a power output that led to exhaustion after about 12.6 min during a placebo (P) control trial. They did this 1.5 h after ingesting either C (5 mg x kg), E (1 mg x kg), C+E, or P. Trials were separated by 1 week. Venous blood was sampled before and during exercise. The mean (SD) times to exhaustion were 12.6 (3.1) (P), 14.4 (4.1) (C), 15.0 (5.7) (E) and 17.5 (5.8) (C+E) min. Only the C+E treatment significantly increased time to exhaustion compared to P. Oxygen consumption (VO2), carbon dioxide production (VCO2), minute ventilation (VE) and the respiratory exchange ratio (RER) were similar during exercise for all trials. Heart rate during exercise was significantly increased for the C+E and C trials compared to P. Subjective ratings of perceived exertion during exercise were significantly lower after C+E compared to P. All treatments significantly increased lactate levels. Free fatty acid (FFA) levels were significantly increased by C ingestion. Glycerol levels were increased by C+E and C ingestion. Glucose levels were also higher with the drug treatments compared to P. Increased monamine availability after C+E treatment was suggested by measurements of catecholamines and dopamine. In conclusion, the combination of C+E significantly prolonged exercise time to exhaustion compared to P, while neither C nor E treatments alone significantly changed time to exhaustion. The improved performance was attributed to increased central nervous system stimulation.
Effects of ephedrine, caffeine, and their combination on muscular endurance.
Jacobs I, Pasternak H, Bell DG.
Defence R&D Canada-Toronto, Canada. Ira.Jacobs@drdc-rddc.gc.ca
PURPOSE: The purpose of this study was to investigate the effects of ingesting caffeine (C), ephedrine (E), and their combination on muscular endurance, using a double-blind, repeated measures design. METHODS: Ninety minutes after ingesting either C (4 mg x kg-1), E (0.8 mg x kg-1), a combination of C+E, or a placebo (P), 13 male subjects performed a weight-training circuit consisting of three supersets (SS), each SS consisting of leg press (at 80% of 1 RM to exhaustion) followed by bench press (at 70% 1-RM to exhaustion); 2 min of rest intervened between SS. RESULTS: The trials involving ephedrine ingestion (C+E and E), when compared with the nonephedrine trials (C and P), caused significant increases (P < 0.05) in the mean number of repetitions completed for both the leg-press and bench-press exercises but only during the first SS. During that first set, the mean number (+/-SD) of repetitions for leg press was 19 +/- 8, 16 +/- 7, 14 +/- 6, and 13 +/- 5 for the C+E, E, C, and P trials, respectively. The mean numbers of repetitions for the first set of bench-press exercise were 14 +/- 3, 13 +/- 3, 12 +/- 3, and 12 +/- 3 for the C+E, E, C, and P trials, respectively. As a result, the total weight lifted during all three sets was greater for the trials involving ephedrine ingestion. Systolic blood pressure before exercise was significantly increased with both ephedrine treatment trials when compared with the other trials (C+E = 156 +/- 29 mm Hg; E = 150 +/- 14; C = 141 +/- 16; P = 138 +/- 14). CONCLUSION: It was concluded that acute ingestion of C+E and E increases muscular endurance during the first set of traditional resistance-training exercise. The performance enhancement was attributed primarily to the effects of E; there was no additive effect of C.
(Just want to comment hear that the significant decrease in output after the first superset may be attributed to the fact that the study was using untrained subjects, and also that 2 minutes is not significant time to allow proper replenishing of creatine stores, especially in untrained subjects)
Effects of caffeine on time to exhaustion in exercise performed below and above the anaerobic threshold.
Denadai BS, Denadai ML.
Departamento de Educacao Fisica, Universidade Estadual Paulista, Rio Claro, SP, Brasil.
Controversy still exists concerning the potential ergogenic benefit of caffeine (CAF) for exercise performance. The purpose of this study was to compare the effects of CAF ingestion on endurance performance during exercise on a bicycle ergometer at two different intensities, i.e., approximately 10% below and 10% above the anaerobic threshold (AT). Eight untrained males, non-regular consumers of CAF, participated in this study. AT, defined as the intensity (watts) corresponding to a lactate concentration of 4 mM, was determined during an incremental exercise test from rest to exhaustion on an electrically braked cycle ergometer. On the basis of these measurements, the subjects were asked to cycle until exhaustion at two different intensities, i.e., approximately 10% below and 10% above AT. Each intensity was performed twice in a double-blind randomized order by ingesting either CAF (5 mg/kg) or a placebo (PLA) 60 min prior to the test. Venous blood was analyzed for free fatty acid, glucose, and lactate, before, during, and immediately after exercise. Rating of perceived exertion and time to exhaustion were also measured during each trial. There were no differences in free fatty acids or lactate levels between CAF and PLA during and immediately after exercise for either intensity. Immediately after exercise glucose increased in the CAF trial at both intensities. Rating of perceived exertion was significantly lower (CAF = 14.1 +/- 2.5 vs PLA = 16.6 +/- 2.4) and time to exhaustion was significantly higher (CAF = 46.54 +/- 8.05) min vs PLA = 32.42 +/- 14.81 min) during exercise below AT with CAF. However, there was no effect of CAF treatment on rating of perceived exertion (CAF = 18.0 +/- 2.7 vs PLA = 17.6 +/- 2.3) and time to exhaustion (CAF = 18.45 +/- 7.28 min vs PLA = 19.17 +/- 4.37 min) during exercise above AT. We conclude that in untrained subjects caffeine can improve endurance performance during prolonged exercise performed below AT and that the decrease of perceived exertion can be involved in this process.
Sorry for the long post, but I believe that you are better off learning from multiple sources.
Anyone that’s interested in more without having to search (which is a real pain in the ass):
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&cmd=Display&dopt=pubmed_pubmed&from_uid=15959797
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Iron and chalk.
Pain is only temporary, it is in your mind. If you can still walk, then you can still run.
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